Normothermic Regional Perfusion (NRP) Services

Unlock the Future of Life-Saving Transplants with Keystone Perfusion

We offer expert NRP Implementation for Next-Level Organ Preservation and Enhanced Recipient Outcomes.

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Addressing the Organ Shortage Crisis with Normothermic Regional Perfusion (NRP)

The field of transplant medicine is rapidly advancing to combat the severe organ shortage crisis. With increasing congressional scrutiny and the demand for more efficient organ use, there’s a growing urgency to optimize the utilization of transplantable organs obtained from donors who have been declared dead by circulatory criteria.

Unlike organs obtained from living or brain-dead donors, those procured from donations after circulatory death (DCD) often face challenges such as hypoxic-ischemic injury. This injury occurs because DCD organs cannot be removed until the donor has been declared dead, typically in the United States after being pulseless for 5 minutes.

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HF-EA-Lee-Pretorius-Fig1-1024x622 Normothermic Regional Perfusion (NRP) Services

The Promise of Normothermic Regional Perfusion (NRP)

Normothermic Regional Perfusion (NRP) represents a groundbreaking approach to organ preservation and assessment. Unlike traditional “ex-vivo” perfusion, NRP utilizes advanced extracorporeal membrane oxygenation (ECMO) or cardiopulmonary bypass technology to restore circulation and perfuse DCD donor organs before recovery. The advantages of NRP are significant:

Reduced Warm Ischemia Time

NRP dramatically reduces warm ischemia time, a critical factor in organ transplant success.

Enhanced Organ Assessment

NRP enables a thorough assessment of DCD donor organs, ensuring optimal transplant outcomes.

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Our Expertise and Comprehensive Solutions

Executing NRP requires technical expertise and a dedicated team. At Keystone Perfusion Services, we offer a comprehensive package of services to guarantee the success of NRP procedures:

Certified Clinical Perfusionists

Our experienced perfusionists are NRP experts, providing unmatched care and precision.

Cutting-Edge Equipment

We supply the latest heart-lung/ECMO equipment available to facilitate NRP procedures.

Disposable Supplies

All necessary disposables are provided to streamline the NRP process.

Pharmaceutical Support

Access to essential medications to support the perfusion process.

Education and Training

Keystone Perfusion Services offers tailored education and training to ensure your team’s proficiency in NRP procedures.

Point-of-Care Testing

We employ advanced point-of-care testing for real-time blood gas analysis, activated clotting time (ACT) monitoring, and lactate level assessment. This ensures that vital parameters are closely monitored and managed during NRP procedures, contributing to improved organ preservation.

Policy and Procedure Development

We assist in developing custom protocols and procedures to align with your institution’s needs.

Ethical Considerations and Transparency

NRP has sparked ethical discussions within the medical community due to the restoration of circulation in a deceased donor. We prioritize transparency and informed consent from donor families in every NRP procedure we undertake.

Dive Deeper into NRP

Explore the following resources to delve deeper into Normothermic Regional Perfusion (NRP) and related discussions:

Learn More about NRP
Stay Informed with Recent News

We are dedicated to delivering exceptional NRP services that can potentially save more lives through organ transplantation. If you have questions or wish to explore how Keystone Perfusion Services can partner with your organization for NRP solutions, please get in touch.

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What Our Clients Are Saying

Keystone Perfusion’s quick, efficient and reliable service has been invaluable to our cardiac program. Throughout the last three years, we have had to call on Keystone Perfusion several times on short notice to provide perfusion coverage for our hospital in different situations. Louis has gone above and beyond to see that we have always had the staff in order to perform our day-to-day perfusion operations.

UPMC Susquehanna

Williamsport, Pennsylvania

For the past several years, Keystone Perfusion Services has provided seamless coverage to Geisinger Healthcare System (GHS) as a locum tenen provider. The seasoned professionals employed by KPS are well trained and have been easily integrated into our complex system. In fact, our Departments operate at full capacity and without delay when KPS is substituting for our staff members.

Geisinger Health System

Wilkes-Barre, Pennsylvania

Keystone Perfusion has helped develop our successful ECMO program by designing an effective ECMO staffing model, improving our quality, and ensuring regulatory compliance. We wholeheartedly recommended Keystone for your ECMO staffing and education needs.

Lancaster General Health

Lancaster, Pennsylvania

Keystone Perfusion Services (KPS) has been an integral part of our Cardiothoracic program at Mercy Health System for the past 2 years. KPS was able to meet our needs quickly and integrate their team into our cardiac surgery program with ease. After arrival, a complete program to meet regulatory agency parameters was established with thorough policy and procedures for perfusion services and maintenance of our perfusion equipment.

Trinity Health

Darby, Pennsylvania

FAQs

Normothermic Regional Perfusion (NRP) is a medical procedure used to preserve organs in a near-physiological state after the donor’s heart has stopped beating. This technique helps in maintaining the organs in a better condition for transplantation.

The key benefits of NRP services include improved organ preservation, which can lead to better outcomes for transplant recipients. By maintaining organs in a near-physiological state, NRP helps in reducing the risk of organ damage during the preservation period.

NRP procedures involve advanced point-of-care testing, including real-time blood gas analysis, activated clotting time (ACT) monitoring, and lactate level assessment. These tests ensure that vital parameters are closely monitored and managed during the procedure.

Point-of-care testing contributes to NRP by allowing for the real-time monitoring of vital parameters such as blood gas levels, clotting times, and lactate levels. This ensures that any necessary adjustments can be made promptly, contributing to the success of the organ preservation process.

Monitoring activated clotting time (ACT) is important during NRP to ensure that the blood remains at an optimal clotting level. This helps in preventing clot formation that could potentially damage the organs being preserved.

Lactate level assessment plays a crucial role in NRP by serving as an indicator of tissue oxygenation and metabolic status. High lactate levels can indicate inadequate oxygen delivery to the organs, necessitating adjustments to the perfusion process to improve organ preservation.

Yes, NRP services can improve the outcome of organ transplants by better-preserving organs and reducing the risk of damage during the preservation period. This can lead to improved function of the transplanted organs and better overall outcomes for recipients.

NRP services can benefit transplant centers, organ procurement organizations, and, ultimately, transplant recipients. By improving the quality of preserved organs, NRP can contribute to more successful transplant outcomes and enhance the lives of those receiving organ transplants.

Let’s Discuss How Keystone Perfusion Services Can Assist in Advancing Your NRP Program.

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